Extracellular Matrix Domain Formation as an Indicator of Chondrocyte Dedifferentiation and Hypertrophy
نویسندگان
چکیده
منابع مشابه
Extracellular Matrix Delays Articular Chondrocyte Dedifferentiation and Enhances Redifferentiation
Introduction Articular cartilage is a highly specialized tissue that is vulnerable to injury and disease and has a limited capacity for self-regeneration. The autologous chondrocyte transplantation technique has not been successful because of rapid dedifferentiation of chondrocytes in monolayer culture, producing fibroblast-specific markers (mainly collagen I) rather than a cartilage-specific m...
متن کاملEffects of concanavalin A on chondrocyte hypertrophy and matrix calcification.
Resting chondrocytes do not usually undergo differentiation to the hypertrophic stage and calcification. However, incubating these cells with concanavalin A resulted in 10-100-fold increases in alkaline phosphatase activity, binding of 1,25(OH)2-vitamin D3, type X collagen synthesis, 45Ca incorporation into insoluble material, and calcium content. On the other hand, other lectins tested (includ...
متن کاملnano-rods zno as an efficient catalyst for the synthesis of chromene phosphonates, direct amidation and formylation of amines
چکیده ندارد.
Effects of mechanical stress on chondrocyte phenotype and chondrocyte extracellular matrix expression
Mechanical factors play a key role in regulating the development of cartilage degradation in osteoarthritis. This study aimed to identify the influence of mechanical stress in cartilage and chondrocytes. To explore the effects of mechanical stress on cartilage morphology, we observed cartilages in different regions by histological and microscopic examination. Nanoindentation was performed to as...
متن کاملEXTENDED REPORT Physiological levels of hydrocortisone maintain an optimal chondrocyte extracellular matrix metabolism
Objective: To investigate the effects of physiological doses of hydrocortisone on synthesis and turnover of cell associated matrix (CAM) by human chondrocytes obtained from normal articular cartilage. Methods: Human articular cartilage cells were obtained from visually intact cartilage of the femoral condyles of five donors and maintained in culture for one week to reach equilibrium in accumula...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Tissue Engineering Part C: Methods
سال: 2014
ISSN: 1937-3384,1937-3392
DOI: 10.1089/ten.tec.2013.0056